Uygar Halis TAZEBAY

CURRICULUM VITAE

PERSONAL DATA

Date & Place of Birth: 3 March 1971, Ankara Turkey
Address: Dept. of Molecular Biology and Genetics
Gebze Technical University
41400 Gebze
Kocaeli, Turkey
Phone: +90 262 605 2522
Fax: +90 262 605 2505
E-mail: tazebay@gtu.edu.tr
Foreign Languages: French, English

ACADEMIC DEGREES

Prof. Dr. Gebze Technical University Molecular Biology and Genetics 2015
Assoc. Prof. Dr. Gebze Institute of Technology Molecular Biology and Genetics 2013
Asst. Prof. Mol. Biology and Genetics – Bilkent University 2000
Ph.D. Genetics and Physiology of Microorganisms University of Paris XI, France 1998
MSc. Genetics and Physiology of Microorganisms University of Paris XI, France 1994
BSc. Biology - Middle East Technical University Ankara, Turkey  1993

EMPLOYMENT HISTORY

7/2015 – Present    Professor / Chairman
Gebze Technical University
Dept. of Molecular Biology and Genetics
Gebze, 41400 Kocaeli, Turkey
1/2013-7/2015 Associate Professor
Gebze Technical University
Dept. of Molecular Biology and Genetics
Gebze, 41400 Kocaeli, Turkey
9/2000 – 1/2013 Assistant Professor
Bilkent University
Dept. of Molecular Biology and Genetics
Bilkent, 06800 Ankara, Turkey
8/1998 - 9/2000 Research Associate
Department of Molecular Pharmacology
Albert Einstein College of Medicine
New York, 10461 NY, USA

PROFESSIONAL AWARDS

Feyzi Akkaya Science Foundation (FABED Foundation) Outstanding Young Investigator Award – 2007

Bilkent University Outstanding Teaching Award – 2003

Turkish Academy of Sciences (TÜBA) Young Investigator Award (Üstün Başarılı Genç Bilim İnsanı Destekleme Programı, GEBIP) – 2002

U.S. Department of Defense, Breast Cancer Research Program, Post-doctoral Traineeship Award – 1999

Medical Research Foundation – France (Fondation Pour La Recherche Medicale) Ph.D Fellowship Award – 1997

NATO Science Fellowship Program (NATO-A1 Ph.D. Fellowship) Scientific and Technical Research Council of Turkey (TUBITAK) – 1994

PEER REVIEWED PUBLICATIONS

  • Telkoparan P, Erkek S, Yaman E, Alotaibi H, Bayik D, and Tazebay UH (2013) Coiled-coil domain-containing protein 124 is a novel centrosome and midbody protein that interacts with the Ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. PLoS One, Vol. 8(7), e-publication: e69289.
  • Akturk M, Sargin-Oruc A, Danisman N, Erkek S, Buyukkagnici U, Unlu E, and Tazebay UH (2013) Na+/I- symporter and type 3 iodothyronine deiodinase gene expression in amniotic membrane and placenta and its relationship to maternal thyroid hormones. Biol. Trace Elem. Res., Vol. 154(3), 338-344.
  • Cevik IS, Keskin N, Belkaya S, Ozlu MI, Tazebay UH, and Erman B (2012) "CD81 interacts with the T-cell receptor to suppress signaling". PLoS One, Vol. 7(11), e-publication: e50396.
  • Yavas S, Erdogan M, Gürel K, Ilday FÖ, Eldeniz YB, and Tazebay UH (2012) Fiber-laser microscope system for femtosecond photodisruption of biological samples. Biomedical Optics Express, Vol. 3(3), 605-611.
  • Erdogan M, Oktem B, Kalaycioglu H, Yavas S, Mukhopadhyay P, Aykac Y, Tazebay UH, and Ilday FÖ (2011) Texturing of titanium (Ti6Al4V) medical implant surfaces with MHz-repetition-rate femtosecond and picosecond Yb-doped lasers. Optics Express, Vol. 19(11), 10986-10996.    
  • Alotaibi H, Yaman E, Salvatore D, Di Dato V, Telkoparan P, Di Lauro R, and Tazebay UH (2010) Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription. Nucleic Acids Research, Vol. 38(10), 3172-3185.
  • Mumcuoglu M, Bagislar S, Yuzugullu H, Alotaibi H, Senturk S, Telkoparan P, Gur-Dedeoglu B, Cingoz B, Bozkurt B, Tazebay UH, Yulug IG, Akcali KC, and Ozturk M (2010) The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity." PLoS One, Vol. 5(6), e-publication: e11288.
  • Yaman E, Gasper R, Koerner C, Wittinghofer A, and Tazebay UH (2009) RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange." FEBS Journal, Vol. 276(16), 4607-4616.
  • Tuncel M, Aydın D, Yaman E, Tazebay UH, Güç D, Doğan AL, Taşbasan B, and Uğur Ö (2007) The comparative effects of gene modulators on thyroid specific genes and radioiodine uptake.” Cancer Biotherapy and Radiopharmaceuticals, Vol. 22(3), 281-288.
  • Alotaibi H, Yaman-Çankaya E, Demirpençe E, Tazebay UH (2006) Unliganded estrogen receptor-alpha activates transcription of the mammary gland Na+/I- symporter gene. Biochemical and Biophysical Research Communications, Vol. 345(4), 1487-1496.
  • Tavoularis SN, Tazebay UH, Diallinas G, Rosa A, Scazzocchio C, and Sophianopoulou V (2003) Mutational analysis of the major proline transporter of (PrnB) of  Aspergillus nidulans.” Molecular Membrane Biology, Vol. 20(4), 285-297.
  • Tazebay UH, Wapnir IL, Levy O, Dohan O, Zuckier LS, Zhao QH, Deng HF, Amenta PS, Fineberg S, Pestell RG, and Carrasco N (2000) The mammary gland iodide transporter is expressed during lactation and in breast cancer.” Nature Medicine, Vol. 6(8), 871-878.
  • Tazebay UH, Sophianopoulou V, Scazzocchio C, and Diallinas G (1997) The gene encoding the major proline transporter of Aspergillus nidulans is upregulated during conidiospore germination and in response to proline induction and amino acid starvation.” Molecular Microbiology, Vol. 24(1), 105-117.
  • Tazebay UH, Sophianopoulou V, Cubero B, Scazzocchio C, and Diallinas G (1995) Post-transcriptional control and kinetic characterization of proline transport in germinating conidiospores of Aspergillus nidulans.” FEMS Microbiology Letters, 132(1), 27-37.
  • Tazebay UH, Sophianopoulou V, Rosa A, Scazzocchio C, and Diallinas G (1994) Structure-function analysis of the proline permease (PrnB) of the filamentous fungus Aspergillus nidulans.” Folia Microbiologica (Prague), Vol. 39(6), 551.

OTHER SCHOLARLY PUBLICATIONS

Ph.D. Dissertation
Analyse mutationelle et étude de la regulation du gène prnB impliqué dans le transport de la proline chez Aspergillus nidulans (Mutational analysis and study on regulation of gene prnB involved in proline uptake in Aspergillus nidulans). Defended on the 10th of July, 1998.
Thesis supervisor: Prof. Dr. Claudio SCAZZOCCHIO, University of Paris-XI, France.

M.Sc Dissertation (Diplome D’Etudes Approfondie, DEA)
Analyse du structure/fonction du gène prnB impliqué dans le transport de la proline chez Aspergillus nidulans (Structure/function analysis of gene prnB involved in proline uptake in Aspergillus nidulans). Defended on the 9th of September, 1994.
Thesis supervisor: Prof. Dr. Claudio SCAZZOCCHIO, University of Paris-XI, France.

Chapters in books or monographs.

  • "Iodine in milk: transport, metabolic implications and relation to endocrine function" in Dietary and Nutritional Aspects of Human Milk, (Edited by Victor P. Reedy, Sherma Zibadi, and Ronald R. Watson). Place of publication: Wageningen Academic Publishers, Wageningen, the Netherlands 2013. Pages: 371-386. Authors: Pelin Telkoparan and Uygar Halis Tazebay.
  • “Regulation of the Functional Na+/I- Symporter (NIS) Expression in Breast Cancer Cells” in Breast Cancer Cells: Book 5 (Edited by Brunhilde Felding-Habermann). Place of publication: INTECH Publishing, Rijeka, Croatia 2011. Pages 103-122. Author: Uygar Halis Tazebay.
  • “Analysis of Genome Evolution as a Tool to Understand the Living Cell (Canlı Hücreyi Anlamak için Bir Araç: Genomların Evrimsel Analizi)” in Bilimden Felsefeye Akademik Bir Çevrenin Serüveni. (Edited by Serap Şahinoğlu, Kumru Arapgirlioğlu, Hürkan Çelebi, Yaman Örs). Place of publication: Bilim ve Gelecek Kitaplığı, Istanbul 2011. Pages 361-369. Authors: Uygar Halis Tazebay and Pelin Telkoparan (in Turkish).
  • “Genetic Regulation in Aspergillus nidulans (Aspergillus nidulans’ta Genetik Regülasyon)” in Aspergillus. (Edited by Beyza Ener) Place of publication: Türk Mikrobiyoloji Cemiyeti Yayını, Istanbul 2006. Vol. 56, pages 82-85. Author: Uygar Halis Tazebay (in Turkish).
  • "Genetic Research and Ethics (Genetik Araştırmalar ve Etik)" in Bilimsel Düşünce ve Araştırmada Etik. (Edited by H. Güven and S. Gidener). Place of publication: Dokuz Eylül Üniversity Publishing, Izmir 2003. Pages 129-140. Author: Uygar Halis Tazebay (in Turkish).

PATENTS

"Methods for the Diagnosis and Treatment of Breast Cancer."
United States Patent No. 7,303,740. Patent filing date: Oct. 8, 2004; Patent date: Dec. 4, 2007. Inventors: Drs. Nancy CARRASCO (New York, USA), Orsolya DOHAN (New York, USA), Uygar H. TAZEBAY (Ankara, Turkey), Irene L. WAPNIR (Stanford, USA).

CURRENT RESEARCH INTERESTS

  • Molecular mechanisms involved in cytokinetic abscission.
  • Cellular and molecular regulation of RasGEF1 (Ras-Guanine Nucleotide Exchange Factor-1)  family of proteins.
  • Hormonal and Molecular Regulation of the Na+/Iodide Symporter (NIS) in Lactating Mammary Gland and in Breast Cancer.