Symposia and Chairs (to be updated)
Advances in Image Analysis
Chair: Nurhan OZLU (Koç University, Turkey) and Çağdaş SON (Middle East Technical University, Turkey)
In accordance with the advancement of microscopes and histochemical techniques in both light and electron microscopy, it is becoming all the more important to extract as much information as possible from the obtained images. This includes quantification and three-dimensional reconstruction, just to name a few. In this session, we hope to discuss both new analytical techniques and practical methods that can be accessed by a broad spectrum of researchers using histochemistry.
Calcified Tissues, Biomaterials and Regenerative Medicine
Chairs: Petek KORKUSUZ (Hacettepe University, Turkey) and Giuseppe MUSUMECI (Catania University, Italy)
This Symposium will address recent advances in the areas of calcified tissues, biomaterials, and tissue regeneration. More specifically, normal and pathological formation of bone and teeth, advances in biomaterials that promote cell interactions and bone formation, and the use of proteins and stem cells for tissue regeneration.
Chairs: Gülperi ÖKTEM (Ege University, Turkey) and Ayhan BİLİR (Istanbul Aydın University Turkey)
Despite a huge effort to find a specific diagnosis and treatment for cancer by increased research, there is no cure for patients in various types of cancer. However, our further researches will hopefully help us understand cancer’s causes and will make us discover new cures. The aim of our efforts is to eradicate cancer, which is a major cause of death. Improving the knowledge of cancer biology and the development of more effective cancer treatments, such as targeted drug therapies, is continuing to be promoted effectively. Immunohistochemistry (IHC) is an extraordinarily powerful tool of monoclonal as well as polyclonal antibodies, to determine the tissue distribution of an antigen of interest in cancer research. This session is aiming to display the cancer biology and the recent researches in this area.
Correlating Light and Electron microscopy
Chairs: Bruno HUMBEL (Lausanne University, Switzerland) and Irına KOLOTUEVA (Lausanne University, Switzerland)
Correlative light - and electron microscopy has become an indispensible tool in medical and cell biological research. Many different methods and approaches were developed from imaging life cells and then studying their morphology at high resolution to using the fluorescence signal as a lighthouse to find the cell of interest in the electron microscope. There are many more imaging technologies possible to combine with light and electron microscopy. This session is meant as a discussion forum for any kind of correlation microscopy.
Developmental and Reproductive Biology
Chair: Çiler ÇELİK ÖZENCİ (Akdeniz University, Turkey) and Cristina PUJADES (Pompeu Fabra University, Spain)
The Developmental and Reproductive Biology session scope is broad, incorporating all from basic scientific advances to laboratory practices. Topics will include recent advances and future developments in developmental biology and reproductive biology. Studies regarding embryology, early pregnancy, reproductive genetics, and reproductive endocrinology are of special interest and wide range of novel microscopy and histochemistry technologies that are being used to investigate the above-mentioned topics will be discussed.
Epigenetics and Molecular Cytogenetics
Chair: Christoph CREMER (The Institute of Molecular Biology- IMB, Germany)
Fundamentals and recent developments of epigenetics and molecular cytogenetics will be discussed during this session. The session focuses on identification and characterisation of novel epigenetic mechanisms related with histogenesis, embryogenesis, carcinogenesis as well as pathogenesis of different diseases and disorders. Bioinformatic approaches to epigenome will also be discussed. Ongoing researches and recent findings about epigenetic placticity will be another exciting topic. The session will give new insights about implications of those novel discoveries on biomarkers of epigenetic and cytogenetic changes and their applicability.
Chairs: John COUCHMAN (Copenhagen University, Denmark) and Sabire KARAÇALI (Ege University, Turkey)
Glycoscience is a rapidly advancing field in the plant and animal sciences. Increasingly it is recognized that post-translational mechanisms add a complex layer of regulation beyond gene expression. Carbohydrates, attached to proteins or lipids, may influence properties of the proteins, e.g. structure and half-life, but also create new binding sites for other macromolecules. Glycosylation can impact development, homeostasis and particularly disease progression. Important fields include innate immunity, extracellular matrix structure and function, tumor progression and host-pathogen interactions. In the post-genomic era, the transferases and other enzymes involved in polysaccharide synthesis are known, but the regulation of their expression, assembly into complexes and glycan interactions with proteins are key topics. This session will present some latest research in glycan biology.
ICDS: Cellular Aging and Cell Death
Chairs: Zahra ZAKERI (Queens College, New York City University, USA) and Richard LOCKSHIN (St. John's University and Queens College, USA)
Cell death affects aging in many ways. In the most well-known situations, many cancers are driven by mutations that decrease the responsiveness of cells to the signals to initiate apoptosis. In other situations, the loss of neurons and the gradual net loss of cells capable of initiating an immune response lead to debility and morbidity. We now understand in considerable detail the process of apoptosis, but this knowledge has led to new questions. If we block one pathway to apoptosis, the cell can still die by another route to apoptosis or another route to death, or if we try to provoke apoptosis, the cell can escape by activating autophagy. In this symposium, experts in the field address the more subtle controls of cell death, how they impact our health, and what we can expect in the near future.
Intracellular Membrane Dynamics
Chair: Hinke MULTHAUPT (Copenhagen University, Denmark)Visualization of cellular dynamics presents challenging tasks for microscopy. This symposium is dedicated to intracellular membrane dynamics in the biosynthetic and endocytic systems, such as antero- and retrograde transport and traffic, organization and remodeling of endoplasmic reticulum, Golgi apparatus and endosomes and assembly of transport carriers. Organelle and vesicle crosstalk and dynamics, together with microscopic and molecular techniques for pathway visualization are addressed in this session. Emphasis is on both normal dynamics and the consequences of disease.
In Vivo Imaging
Chairs: Ralph MEUWISSEN (Izmir Biomedicine and Genome Center, Turkey) and Alper Özgür KARAÇALIOĞLU (Gülhane Education and Research Hospital,Turkey)
Session will cover diverse application methods to visualize living animals and living cells. The dynamics real-time localization and translocation of molecules in living cells and their integral cellular function, and also molecular and cellular dynamic at the organs or tissues in animals responding to physiological or environmental changes can be investigated by using in vivo imaging. Optical in vivo imaging methods are being applied in preclinical researches such as oncology, neurology, cardiology, inflammation, infectious diseases, cancer research, functional and anatomical neuroimaging. New applications based on advanced genetic engineering and improved imaging technologies for in vivo cellular and molecular imaging will be discussed in this session.
Mass Spectrometry Imaging
Chair: Murat KASAP ( Kocaeli University, Turkey)
Mass spectrometry imaging (MSI) is an importantly growing field to study molecules from the macro to nanoscale in 2D and 3D and in real-time. MSI is used to visualize the spatial distribution of chemical compositions e.g. compounds, biomarkers, metabolites, peptides or proteins by their molecular masses. In this session the principal techniques allowing true label-free molecular imaging of biological tissue sections will be discussed.
Chairs: Selma YILMAZER (Istanbul University, Turkey) and Marc DAVENNE - (Universite Pierre et Marie Curie, France)
Neurobiology is an exciting and dramatically developing area. Diverse and groundbreaking approaches to investigate neural development, neural circuit assembly, synaptic plasticity,molecular basis of behavior, brain disorders and regenerative neuroscience have led to tremendous breakthroughs in modern neurobiology. These advances have attracted efforts to understand the mechanisms of normal brain functions and to develop therapeutic targets for brain disorders. The goal of this symposium is to focus on new techniques for imaging of individual neurons, axons, synapses and molecules within neurons and to discuss the most recent advances in the field and to stimulate new directions in neurobiology research.
Pathology and Clinical Medicine
Chair: Hale KIRIMLIOĞLU (Acıbadem University, Turkey) The purpose of this session is to introduce the concepts of pathological and clinical development to researches. The session includes wide variety of issues such as morphologic and functional changes associated with cell injury and death, inflammation, response to microorganisms, cancer biology and organ system pathology, pathology driven by inflammation, protein modification and molecular basis of human diseases.
Chairs: Erdal KARAÖZ (Liv Hospital, Turkey) and Mariusz Z. RATAJCZAK (University of Louisville's , USA)
Stem cells are undifferentiated cells and they can differentiate into specialized cells. In mammals, there are two broad types of stem cells: embryonic stem cells (pluripotent stem cells), which are isolated from the inner cell mass of blastocytes, and adult stem cells, which are found in various tissues, organs and body fluids. On the other hand, using genetic reprogramming with protein transcription factors, pluripotent stem cells equivalent to embryonic stem cells have been derived from human adult skin tissue. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. This symposium will focus on recent advances, the biological properties, future directions of adult stem cell therapies and stem cell therapy approaches which are contributing to the progression of ischemic cardiomyopathies.
Structure and Function of the Cell
Chair: Uygar Halis TAZEBAY (Gebze Technical University, Turkey)
The session will focus on the structural and functional aspects of the cell including organelle structure and organization, intracellular transport and dynamics, cell shape and its dynamic changes, cell motility, cell differentiation, responses to cellular intercellular and intracellular signalling, cellular morphogenesis of cell compartments, cellular metabolism, cell adhesion, cell migration, cell division.
Techniques in Immunohistochemistry
Chair: Alberto LUINI (National Research Council of Italy, Italy)
Immunohistochemistry is a method for localizing cellular or tissue components through antigen-antibody interactions. The field of immunohistochemistry has shown significant advance in recent years and it continues to be an indispensible part of experimental and clinical studies. Novel techniques have rapidly emerged in this field and their application remains growing. One- and two-photon fluorescence imaging in conjunction with time-resolved photoluminescence is one of these promising techniques.
The Cell Nucleus: Structure, Dynamics and Genetics
Chairs: Pavel HOZAK (Institute of Molecular Genetics of the ASCR, Czech Republic) and Dean A. JACKSON (The University of Manchester, UK)
The session will cover a broad range of structural and functional topics on the cell nucleus, including chromosome structure and organization, epigenetic modifications and chromatin remodelling, genome stability, replication and repair, nuclear RNA, nuclear periphery, envelope and lamina, intranuclear metabolism, and nuclear diseases. Progressive methods helping to uncover nuclear functions will be addressed as well.